Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
China must walk a narrow line at a time when its outgoing leadership is reluctant to take any far-sighted decisions.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
It is the first time since 2001 that an athlete other than Mayweather Jnr or golfer Tiger Woods topped the earning league.
Next year, the mayor’s affordable housing plan, which calls for building or preserving 200,000 units of affordable housing over the next decade, will begin to take shape. It hinges on a policy that requires developers to build affordable housing in exchange for being allowed to construct taller and denser buildings in neighborhoods rezoned by the city. Developers and housing advocates alike are waiting to see what it will look like once the administration adds muscle and flesh to the bones of the proposal.
Trends and targets in antiviral phototherapy
The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.
The scientists’ analysis comes only a month after nearly 200 governments struck a new climate agreement in Paris that aims to stop global temperatures from rising more than 2C from pre-industrial levels, and ideally limit warming to 1.5C.
除了跳舞，玛蒂还唱歌和表演，她已经出演了电视剧《美女上错身》(Drop Dead Diva)和《奥斯汀与艾丽》(Austin & Ally)。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
INDOORS: This house was completed around 1848 and last updated in 2008. The front door has a transom and sidelights of red glass etched with a leaf motif. The first floor has a large living room with crown molding and two fireplaces, one of which warms the formal dining area. Off the living room is a family room with raised wall paneling, a wet bar and another dining area. French doors open to a slate patio. Several rooms have views of Little Narragansett Bay.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
That cold was drawn into the interior of the country by a loop in a current called the jet stream that allowed Arctic air to spill southward. But an offsetting kink allowed unusually warm tropical air to settle over the West, large parts of Alaska and much of the Arctic.
Diagnostic technologies for COVID-19: a review
STEP 6: FIND A WATSON
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Charli XCX, 'Number 1 Angel'
Emily Ratajkowski managed to steal the show, opting for a seriously saucy twist on the classic ballgown. Opting for a semi-sheer lacey black number, the We Are Your Friends actress ensured her world-famous figure was on display.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Wang Dengfeng, director of the Physical Education, Health and Art Department under the Ministry of Education (MOE) and Vice Chairman of the China Football Association, was quoted as saying that football experts are designing curriculums for more than 360 training programs in primary and secondary schools.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Song “Family”(Tan Jing)
Antiviral drug discovery: broad-spectrum drugs from nature
US president Donald Trump’s zero-sum, Art-of-the-Deal approach to negotiation will give comfort to old-fashioned incumbents. I am hoping 2018 will provide an opportunity for positive, problem-solving new leaders to emerge. But change could stall if business chiefs, disheartened by the poor quality of political leadership, turn inwards instead.
"How many patients do Chinese doctors see a day? It can be more than 50," he told China Daily. "How can we have the time and energy to do research or publish papers?"
Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.
Influenza neuraminidase: A druggable target for natural products
The details of her character are being kept under wraps.
I mean, is it worth to be a No. 8 seed with Serge Ibaka and Jeff Green leading the way? Maybe it is. This all just seems awfully backwards.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
特里萨?梅(Theresa May)依然面临着党内阻力。自由民主党(Liberal Democrats)的智者兼领导人文斯?凯布尔(Vince Cable)依然认为脱欧可能不会真的发生。
The role of biosensors in the detection of emerging infectious diseases
Exports to the EU, Japan and Hong Kong — which serves as a transit point for exports to many other parts of the world — fell by 4.1 per cent, 9.5 per cent and 12.2 per cent respectively.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
《傲骨贤妻》(The Good Wife)：艾丽西娅(Alicia)的秘密暧昧对象威尔（Will，乔希·查尔斯[Josh Charles]饰）在第五季末死去，CBS频道的这部性感法庭剧似乎要完蛋了，但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美，《傲骨贤妻》因此更好看了。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.
8. Taxi driver
n. 没精打采的样子，耷拉，笨人 v. 没精打采地站，坐
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
But there's even more to be excited about: Magic Johnson is a well-connected and well-respected Hall of Famer who seems smart enough to delegate, new GM Rob Pelinka is a proven deal-maker with extensive ties throughout the league,
Inhibition of SARS coronavirus helicase by bismuth complexes
He and his girlfriend wrote to each other when he was studying science, he said.They did eventually marry and have four children.
A report on entrepreneurship among Chinese college students published by Renmin University of China revealed an inverse proportion between the level of students' academic degrees and their intentions to start their own businesses.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
WHAT: A riverfront contemporary with three bedrooms and three and a half bathrooms
It organized two large-scale inspections last year, involving more than 5,300 batches of imported consumer goods, such as air purifiers, car brake blocks, household electrical appliances and clothes, with more than 1,500 found to be substandard, Han said.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Obama watched the returns on television at his Chicago home. Senior campaign strategist David Axelrod said via email that he was feeling "great."
The announcement comes from the British Fashion Council (BFC), who surveyed designers ahead of the shows and found none of the 80 designers in the September line-up would be using fur.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
over $50,000 category, pickups and SUVs distributed through non-premium dealers outsell German luxury brands.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Fiat will seek to renegotiate the terms of its investment in Chrysler.
10.Supersensitive Electronic Skin
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
That creates an identity vacuum to be filled.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
A teenage student in Southwest China's Chongqing Municipality has been sentenced to one year in jail after trying to poison fellow students for being too noisy in class, local media reported last Wednesday.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
BuzzFeed News defined “fake news” as news that was verifiably “100 percent false” and drawn from a list of 96 websites purposely created to disseminate false information.
That Apple could launch a 2,000 yuan ($330) iPhone mini and be competitive with flagship products from Lenovo, Huawei, ZTE and Coolpad.
在上榜的90所欧洲商学院中，法国的欧洲工商管理学院(Insead)在全日制MBA课程和EMBA课程方面居首，瑞士圣加伦大学(St Gallen)的管理硕士课程排名第一。西班牙Iese商学院(Iese Business School)和瑞士洛桑国际管理发展学院(IMD)分别在定制和开放注册高管教育课程上夺魁。
Tesla:In an effort to blunt criticism about slow refueling times for battery-powered cars, Tesla TSLA -1.54% starts to roll out of a network of battery-swap stations. CEO Elon Musk must hope he can outdo Shai Agassi’s Better Place, which tried to build a whole company around battery-swaps before going bankrupt in 2013.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Baby Driver recently placed on the National Board of Review’s Top 10 list. The film holds a 93% on Rotten Tomatoes and took in over $100 million dollars at the box office.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Jack Ma, founder and executive chairman of e-commerce giant Alibaba Group topped the ranking of China's richest IT people for the third consecutive year.
9. Smart wine bottle
The magazine also notes that he gave $66 million to his presidential campaign and paid $25 million to settle a lawsuit related to Trump University.
Tracey and Viv Williams, a British couple, dressed as the green cartoon ogres from Shrek at their wedding held recently. Tracy, 33, made a lovely Princess Fion
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Brazil lost that 1950 final, 2-1, to Uruguay, a historic humiliation that still stings Brazilian fans today. Belmonte, 85, hopes he'll get to see his country regain its honor. "I hope Brazil will be able to win this time," he said. "This is our revenge. I want to go see our revenge."
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The drama and the original game have a large fan base and enjoy great popularity in China, and even elsewhere in Asia.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
And the public chose Callabro to be crowned this year's winner, where they will take home a ￡250,000 cash prize and a spot at this year's Royal Variety Performance.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The rest of them, he goes over quickly:
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
8. Trang Islands, Thailand-The islands of Trang, a sleepy province in southeast Thailand, have remained under the radar. Wooden longtail boats can be rented to travel between the islands—and to see the endangered dugongs.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Joakim Noah, meanwhile, proved to be so untradeable that he couldn't even generate a rumor.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Welcome as they were, surging sales weren't the biggest news of the year. Detroit celebrated when General Motors (GM, Fortune 500) made Mary Barra the auto industry's first female CEO, then held its breath while Ford (F, Fortune 500) CEO Alan Mulally dithered over a move to Seattle and Microsoft. The old Big Three, complaining about straining available production capacity, made plans to expand and hire. Tesla(TSLA) fired up electric car sales and refused to play by industry's rules, while Google(GOOG, Fortune 500) pioneered a car that drives itself.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Figures released by the International Society of Aesthetic Plastic Surgery (ISAPS), suggest that when population is taken into account, South Korea is now the world's largest market for cosmetic procedures.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
1.Under no circumstances should you ask your taxi driver how excited he is about having the Olympics in London this summer. It's not that he will be reluctant or embarrassed to offer a personal opinion on the matter. That is not the problem at all.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
4. Add Color
A facile assay for rapid detection of COVID-19 antibodies
The country's film output ranks third in the global market and is expected to exceed 700 by the end of 2016. Sales of film rights to online video sites raked in 4 billion yuan (560 million U.S. dollars) in the same period.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
I know many of you met your former spouse at the company. But the thing is, for every one of you, there are five people it doesn't work out as well for. And your office romance can and will be held against you.
5. 范冰冰 1700万美元
China will "fasten the seat belt" and prevent any "acute outburst" of financial risks on the track for maintaining medium-high growth speed.
5. Geopolitical flashpoints.In the not too distant past, a small supply disruption would send oil prices skyward. In early 2014, for example, violence in Libya blocked oil exports, contributing to a rise in oil prices. In Iraq, ISIS overran parts of the country and oil prices shot up on fears of supply outages. But since then, geopolitical flashpoints have had much less of an effect on the price of crude. During the last few weeks of 2014, violence flared up again in Libya. But after a brief increase in prices, the markets shrugged off the event. Nevertheless, history has demonstrated time and again that geopolitical crises are some of the most powerful short-term movers of oil prices.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
"He promised when he took office that he would have a Cabinet that was 50 percent women, and then he did it," Maddow said. "Would you make that same pledge?"
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
According to the report, people living in first-tier cities such as Beijing, Shanghai, Guangzhou and Shenzhen suffer much higher economic pressure, while fourth-tier and smaller cities offer fewer job opportunities and connection plays an important role in every aspect of life there.
Length-scale dependence of protein hydration-shell density
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
As we ring in the New Year, let’s take stock of where we are at with the oil markets. 2014 proved to be a momentous one for the oil markets, having seen prices cut in half in just six months.
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Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.
Whatever happened to ‘Never complain; never explain' – the unofficial motto of the House of Windsor?